Nerlov Group (Visiting)Publications
Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.
Bereshchenko, O., Mancini, E., Moore, S., Bilbao, D., Mansson, R., Luc, S., Grover, A., Jacobsen, S.E., Bryder, D. & Nerlov, C.
Cancer Cell. 2009 Nov 6;16(5):390-400.
PubMed
C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Lopez, R.G., Garcia-Silva, S., Moore, S.J., Bereshchenko, O., Martinez-Cruz, A.B., Ermakova, O., Kurz, E., Paramio, J.M. & Nerlov, C.
Nat Cell Biol. 2009 Oct;11(10):1181-90. Epub 2009 Sep 13.
PubMed
Targeting a chronic problem: elimination of cancer stem cells in CML.
Nerlov, C.
EMBO J. 2009 Feb 4;28(3):167-8.
PubMed
KEPE--a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factors.
Diella, F., Chabanis, S., Luck, K., Chica, C., Ramu, C., Nerlov, C. & Gibson, T.J.
Bioinformatics. 2009 Jan 1;25(1):1-5. Epub 2008 Nov 24.
PubMed
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.
Weischenfeldt, J., Damgaard, I., Bryder, D., Theilgaard-Monch, K., Thoren, L.A., Nielsen, F.C., Jacobsen, S.E., Nerlov, C. & Porse, B.T.
Genes Dev. 2008 May 15;22(10):1381-96.
PubMed
Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.
Hasemann, M.S., Damgaard, I., Schuster, M.B., Theilgaard-Monch, K., Sorensen, A.B., Mrsic, A., Krugers, T., Ylstra, B., Pedersen, F.S., Nerlov, C. & Porse, B.T.
Blood. 2008 Apr 15;111(8):4309-21. Epub 2008 Jan 22.
PubMed
Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.
Kirstetter, P., Schuster, M.B., Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Monch, K., Mansson, R., Pedersen, T.A., Pabst, T., Schrock, E., Porse, B.T., Jacobsen, S.E., Bertone, P., Tenen, D.G. & Nerlov, C.
Cancer Cell. 2008 Apr;13(4):299-310.
PubMed
The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.
Nilsson, L., Eden, P., Olsson, E., Mansson, R., Astrand-Grundstrom, I., Strombeck, B., Theilgaard-Monch, K., Anderson, K., Hast, R., Hellstrom-Lindberg, E., Samuelsson, J., Bergh, G., Nerlov, C., Johansson, B., Sigvardsson, M., Borg, A. & Jacobsen, S.E.
Blood. 2007 Oct 15;110(8):3005-14. Epub 2007 Jul 6.
PubMed
Regulation of self-renewal and leukemogenesis by C/EBP alpha.
Nerlov, C
Experimental Hematology 2007 35(9)
The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.
Nerlov, C.
Trends Cell Biol. 2007 Jul;17(7):318-24. Epub 2007 Jul 19.
PubMed
Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.
Fujimoto, T., Anderson, K., Jacobsen, S.E., Nishikawa, S.I. & Nerlov, C.
EMBO J. 2007 May 2;26(9):2361-70. Epub 2007 Apr 12.
PubMed
Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes.
Anderson, K., Rusterholz, C., Mansson, R., Jensen, C.T., Bacos, K., Zandi, S., Sasaki, Y., Nerlov, C., Sigvardsson, M. & Jacobsen, S.E.
Blood. 2007 May 1;109(9):3697-705. Epub 2007 Jan 11.
PubMed
Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.
Pedersen, T.A., Bereshchenko, O., Garcia-Silva, S., Ermakova, O., Kurz, E., Mandrup, S., Porse, B.T. & Nerlov, C.
EMBO J. 2007 Feb 21;26(4):1081-93. Epub 2007 Feb 8.
PubMed
Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.
Calella, A.M., Nerlov, C., Lopez, R.G., Sciarretta, C., von Bohlen Und Halbach, O., Bereshchenko, O. & Minichiello, L.
Neural Develop. 2007 Jan 25;2:4.
PubMed
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.
Kirstetter, P., Anderson, K., Porse, B.T., Jacobsen, S.E. & Nerlov, C.
Nat Immunol. 2006 Oct;7(10):1048-56. Epub 2006 Sep 3.
PubMed
Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.
Liew, C.W., Rand, K.D., Simpson, R.J., Yung, W.W., Mansfield, R.E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F.M. & Mackay, J.P.
J Biol Chem. 2006 Sep 22;281(38):28296-306. Epub 2006 Jul 20.
PubMed
The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.
Porse, B.T., Pedersen, T.A., Hasemann, M.S., Schuster, M.B., Kirstetter, P., Luedde, T., Damgaard, I., Kurz, E., Schjerling, C.K. & Nerlov, C.
Mol Cell Biol. 2006 Feb;26(3):1028-37.
PubMed
Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.
Porse, B.T., Bryder, D., Theilgaard-Monch, K., Hasemann, M.S., Anderson, K., Damgaard, I., Jacobsen, S.E. & Nerlov, C.
J Exp Med 2005 Jul 4;202(1):85-96. Epub 2005 Jun 27.
PubMed
Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.
Bakri, Y., Sarrazin, S., Mayer, U.P., Tillmanns, S., Nerlov, C., Boned, A. & Sieweke, M.H.
Blood 2005 Apr 1;105(7):2707-16. Epub 2004 Dec 14.
PubMed
C/EBPalpha mutations in acute myeloid leukaemias.
Nerlov, C.
Nat Rev Cancer 2004 May;4(5):394-400.
PubMed
The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.
D'Alo', F., Johansen, L.M., Nelson, E.A., Radomska, H.S., Evans, E.K., Zhang, P., Nerlov, C. & Tenen, D.G.
Blood 2003 Nov 1;102(9):3163-71. Epub 2003 Jul 17.
PubMed
Cell cycle inhibition mediated by the outer surface of the C/EBPalpha basic region is required but not sufficient for granulopoiesis.
Wang, Q.F., Cleaves, R., Kummalue, T., Nerlov, C. & Friedman, A.D.
Oncogene 2003 May 1;22(17):2548-57.
PubMed
Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency.
van Wijk, R., van Solinge, W.W., Nerlov, C., Beutler, E., Gelbart, T., Rijksen, G. & Nielsen, F.C.
Blood 2003 Feb 15;101(4):1596-602.
PubMed
Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.
Pedersen-Bjergaard, J., Andersen, M.K., Christiansen, D.H. & Nerlov, C.
Blood 2002 Mar 15;99(6):1909-12.
PubMed
Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.
Pedersen, T.A., Kowenz-Leutz, E., Leutz, A. & Nerlov, C.
Genes Dev 2001 Dec 1;15(23):3208-16.
PubMed
E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.
Porse, B.T., Pedersen, T.A., Xu, X., Lindberg, B., Wewer, U.M., Friis-Hansen, L. & Nerlov, C.
Cell 2001 Oct 19;107(2):247-58.
PubMed
Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.
Querfurth, E., Schuster, M., Kulessa, H., Crispino, J.D., Doderlein, G., Orkin, S.H., Graf, T. & Nerlov, C.
Genes Dev 2000 Oct 1;14(19):2515-25.
PubMed
GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription.
Nerlov, C., Querfurth, E., Kulessa, H. & Graf, T.
Blood 2000 Apr 15;95(8):2543-51.
PubMed
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.
Nerlov, C., McNagny, K.M., Doderlein, G., Kowenz-Leutz, E. & Graf, T.
Genes Dev 1998 Aug 1;12(15):2413-23.
PubMed
PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.
Nerlov, C. & Graf, T.
Genes Dev 1998 Aug 1;12(15):2403-12.
PubMed
Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1.
McNagny, K.M., Sieweke, M.H., Doderlein, G., Graf, T. & Nerlov, C.
EMBO J 1998 Jul 1;17(13):3669-80.
PubMed
CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells.
Nerlov, C. & Ziff, E.B.
EMBO J 1995 Sep 1;14(17):4318-28.
PubMed
Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter.
Nerlov, C. & Ziff, E.B.
Genes Dev 1994 Feb 1;8(3):350-62.
PubMed