O'Carroll GroupPublications
The miR-144/451 locus is required for erythroid homeostasis.
Rasmussen, K.D., Simmini, S., Abreu-Goodger, C., Bartonicek, N., Di Giacomo, M., Bilbao-Cortes, D., Horos, R., Von Lindern, M., Enright, A.J. & O'Carroll, D.
J Exp Med. 2010 May 31.
PubMed
DGCR8-dependent microRNA biogenesis is essential for skin development.
Yi, R., Pasolli, H.A., Landthaler, M., Hafner, M., Ojo, T., Sheridan, R., Sander, C., O'Carroll, D., Stoffel, M., Tuschl, T. & Fuchs, E.
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):498-502. Epub 2008 Dec 29.
PubMed
Essential role for Argonaute2 protein in mouse oogenesis.
Kaneda, M., Tang, F., O'Carroll, D., Lao, K. & Surani, M.A.
Epigenetics Chromatin. 2009 Aug 10;2(1):9.
PubMed
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
Liston, A., Lu, L.F., O'Carroll, D., Tarakhovsky, A. & Rudensky, A.Y.
J Exp Med. 2008 Sep 1;205(9):1993-2004. Epub 2008 Aug 25.
PubMed
A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway.
O'Carroll, D., Mecklenbrauker, I., Das, P.P., Santana, A., Koenig, U., Enright, A.J., Miska, E.A. & Tarakhovsky, A.
Genes Dev. 2007 Aug 15;21(16):1999-2004. Epub 2007 Jul 12.
PubMed
Cerebellar neurodegeneration in the absence of microRNAs.
Schaefer, A., O'Carroll, D., Tan, C.L., Hillman, D., Sugimori, M., Llinas, R. & Greengard, P.
J Exp Med. 2007 Jul 9;204(7):1553-8. Epub 2007 Jul 2.
PubMed
Maternal microRNAs are essential for mouse zygotic development.
Tang, F., Kaneda, M., O'Carroll, D., Hajkova, P., Barton, S.C., Sun, Y.A., Lee, C., Tarakhovsky, A., Lao, K. & Surani, M.A.
Genes Dev. 2007 Mar 15;21(6):644-8.
PubMed
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.
Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A. & Fuchs, E.
Cell. 2006 Aug 11;126(3):597-609.
PubMed
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.
Yi, R., O'Carroll, D., Pasolli, H.A., Zhang, Z., Dietrich, F.S., Tarakhovsky, A. & Fuchs, E.
Nat Genet. 2006 Mar;38(3):356-62. Epub 2006 Feb 5.
PubMed
220-plex microRNA expression profile of a single cell.
Tang, F., Hajkova, P., Barton, S.C., O'Carroll, D., Lee, C., Lao, K. & Surani, M.A.
Nat Protoc. 2006;1(3):1154-9.
PubMed
Germline recruitment in mice: a genetic program for epigenetic reprogramming.
Ohinata, Y., Seki, Y., Payer, B., O'Carroll, D., Surani, M.A. & Saitou, M.
Ernst Schering Res Found Workshop. 2006;(60):143-74.
PubMed
Blimp1 and the emergence of the germ line during development in the mouse.
Saitou, M., Payer, B., O'Carroll, D., Ohinata, Y. & Surani, M.A.
Cell Cycle. 2005 Dec;4(12):1736-40. Epub 2005 Dec 27.
PubMed
Blimp1 is a critical determinant of the germ cell lineage in mice.
Ohinata, Y., Payer, B., O'Carroll, D., Ancelin, K., Ono, Y., Sano, M., Barton, S.C., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., Saitou, M. & Surani, M.A.
Nature. 2005 Jul 14;436(7048):207-13. Epub 2005 Jun 5.
PubMed
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression.
Lagger, G., O'Carroll, D., Rembold, M., Khier, H., Tischler, J., Weitzer, G., Schuettengruber, B., Hauser, C., Brunmeir, R., Jenuwein, T. & Seiser, C.
EMBO J. 2002 Jun 3;21(11):2672-81.
PubMed
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.
Peters, A.H., Mermoud, J.E., O'Carroll, D., Pagani, M., Schweizer, D., Brockdorff, N. & Jenuwein, T.
Nat Genet. 2002 Jan;30(1):77-80. Epub 2001 Dec 10.
PubMed
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Peters, A.H., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schofer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., Opravil, S., Doyle, M., Sibilia, M. & Jenuwein, T.
Cell. 2001 Nov 2;107(3):323-37.
PubMed
Rb targets histone H3 methylation and HP1 to promoters.
Nielsen, S.J., Schneider, R., Bauer, U.M., Bannister, A.J., Morrison, A., O'Carroll, D., Firestein, R., Cleary, M., Jenuwein, T., Herrera, R.E. & Kouzarides, T.
Nature. 2001 Aug 2;412(6846):561-5.
PubMed
The polycomb-group gene Ezh2 is required for early mouse development.
O'Carroll, D., Erhardt, S., Pagani, M., Barton, S.C., Surani, M.A. & Jenuwein, T.
Mol Cell Biol. 2001 Jul;21(13):4330-6.
PubMed
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T.
Nature. 2001 Mar 1;410(6824):116-20.
PubMed
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression.
O'Carroll, D., Scherthan, H., Peters, A.H., Opravil, S., Haynes, A.R., Laible, G., Rea, S., Schmid, M., Lebersorger, A., Jerratsch, M., Sattler, L., Mattei, M.G., Denny, P., Brown, S.D., Schweizer, D. & Jenuwein, T.
Mol Cell Biol. 2000 Dec;20(24):9423-33.
PubMed
Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B.D., Sun, Z.W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C.P., Allis, C.D. & Jenuwein, T.
Nature. 2000 Aug 10;406(6796):593-9.
PubMed
The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6.
Laible, G., Haynes, A.R., Lebersorger, A., O'Carroll, D., Mattei, M.G., Denny, P., Brown, S.D. & Jenuwein, T.
Mamm Genome. 1999 Mar;10(3):311-4.
PubMed