Staff at EMBL

Manlio Vinciguerra

Postdoctoral Fellow (EIPOD)
Ladurner Group
Rosenthal Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Publications

Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 is a major regulator of muscle mass during growth but not for adult myofiber hypertrophy. Vinciguerra, M., Hede, M. & Rosenthal, N. J Appl Physiol. 2010 Jun;108(6):1829-30. PubMed

Effects of the peroxisome proliferator-activated receptor (PPAR)-gamma agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals. Zanchi, A., Maillard, M., Jornayvaz, F.R., Vinciguerra, M., Deleaval, P., Nussberger, J., Burnier, M. & Pechere-Bertschi, A. Diabetologia. 2010 Apr 23. PubMed

HCV core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells. Pazienza, V., Vinciguerra, M., Andriulli, A. & Mangia, A. J Gen Virol. 2010 Mar 31. PubMed

SirT1 in muscle physiology and disease: lessons from mouse models. Vinciguerra, M., Fulco, M., Ladurner, A., Sartorelli, V. & Rosenthal, N. Dis Model Mech. 2010 Mar 30. PubMed

Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Vinciguerra, M., Santini, M.P., Claycomb, W.C., Ladurner, A.G. & Rosenthal, N. Aging (Albany NY). 2009 Dec 10;2(1):43-62. PubMed

The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue. Veyrat-Durebex, C., Montet, X., Vinciguerra, M., Gjinovci, A., Meda, P., Foti, M. & Rohner-Jeanrenaud, F. Am J Physiol Endocrinol Metab. 2009 May;296(5):E1120-32. Epub 2009 Feb 10. PubMed

Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN. Vinciguerra, M., Carrozzino, F., Peyrou, M., Carlone, S., Montesano, R., Benelli, R. & Foti, M. J Hepatol. 2009 Apr 1. PubMed

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. Vinciguerra, M., Sgroi, A., Veyrat-Durebex, C., Rubbia-Brandt, L., Buhler, L.H. & Foti, M. Hepatology. 2009 Apr;49(4):1176-84. PubMed

Aldosterone, but not increased Na+ influx or NF-kappaB activation, increases kidney-specific WNK1 gene expression in renal collecting duct cells. Vinciguerra, M. Horm Metab Res. 2009 Jan;41(1):67-70. Epub 2008 Oct 27. PubMed

Aldosterone activates NF-kappaB in the collecting duct. Leroy, V., De Seigneux, S., Agassiz, V., Hasler, U., Rafestin-Oblin, M.E., Vinciguerra, M., Martin, P.Y. & Feraille, E. J Am Soc Nephrol. 2009 Jan;20(1):131-44. Epub 2008 Nov 5. PubMed

PTEN at the crossroad of metabolic diseases and cancer in the liver. Vinciguerra, M. & Foti, M. Ann Hepatol. 2008 Jul-Sep;7(3):192-9. PubMed

Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Cederroth, C.R., Vinciguerra, M., Gjinovci, A., Kuhne, F., Klein, M., Cederroth, M., Caille, D., Suter, M., Neumann, D., James, R.W., Doerge, D.R., Wallimann, T., Meda, P., Foti, M., Rohner-Jeanrenaud, F., Vassalli, J.D. & Nef, S. Diabetes. 2008 May;57(5):1176-85. Epub 2008 Apr 16. PubMed

PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. Vinciguerra, M., Veyrat-Durebex, C., Moukil, M.A., Rubbia-Brandt, L., Rohner-Jeanrenaud, F. & Foti, M. Gastroenterology. 2008 Jan;134(1):268-80. Epub 2007 Oct 10. PubMed

A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice. Cederroth, C.R., Vinciguerra, M., Kuhne, F., Madani, R., Doerge, D.R., Visser, T.J., Foti, M., Rohner-Jeanrenaud, F., Vassalli, J.D. & Nef, S. Environ Health Perspect. 2007 Oct;115(10):1467-73. PubMed

Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes. De Gottardi, A., Vinciguerra, M., Sgroi, A., Moukil, M., Ravier-Dall'Antonia, F., Pazienza, V., Pugnale, P., Foti, M. & Hadengue, A. Lab Invest. 2007 Aug;87(8):792-806. Epub 2007 Jun 11. PubMed

PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling. Vinciguerra, M. & Foti, M. Arch Physiol Biochem. 2006 Apr;112(2):89-104. PubMed

Hormonal and nonhormonal mechanisms of regulation of the NA,K-pump in collecting duct principal cells. Vinciguerra, M., Mordasini, D., Vandewalle, A. & Feraille, E. Semin Nephrol. 2005 Sep;25(5):312-21. PubMed

Cytokines and sodium induce protein kinase A-dependent cell-surface Na,K-ATPase recruitment via dissociation of NF-kappaB/IkappaB/protein kinase A catalytic subunit complex in collecting duct principal cells. Vinciguerra, M., Hasler, U., Mordasini, D., Roussel, M., Capovilla, M., Ogier-Denis, E., Vandewalle, A., Martin, P.Y. & Feraille, E. J Am Soc Nephrol. 2005 Sep;16(9):2576-85. Epub 2005 Jul 6. PubMed

Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cells. Hasler, U., Vinciguerra, M., Vandewalle, A., Martin, P.Y. & Feraille, E. J Am Soc Nephrol. 2005 Jun;16(6):1571-82. Epub 2005 Apr 20. PubMed

Extracellular hypotonicity increases Na,K-ATPase cell surface expression via enhanced Na+ influx in cultured renal collecting duct cells. Vinciguerra, M., Arnaudeau, S., Mordasini, D., Rousselot, M., Bens, M., Vandewalle, A., Martin, P.Y., Hasler, U. & Feraille, E. J Am Soc Nephrol. 2004 Oct;15(10):2537-47. PubMed

Intracellular Na+ controls cell surface expression of Na,K-ATPase via a cAMP-independent PKA pathway in mammalian kidney collecting duct cells. Vinciguerra, M., Deschenes, G., Hasler, U., Mordasini, D., Rousselot, M., Doucet, A., Vandewalle, A., Martin, P.Y. & Feraille, E. Mol Biol Cell. 2003 Jul;14(7):2677-88. Epub 2003 Apr 4. PubMed

Mechanism of control of Na,K-ATPase in principal cells of the mammalian collecting duct. Feraille, E., Mordasini, D., Gonin, S., Deschenes, G., Vinciguerra, M., Doucet, A., Vandewalle, A., Summa, V., Verrey, F. & Martin, P.Y. Ann N Y Acad Sci. 2003 Apr;986:570-8. PubMed